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The effectiveness of SCENAR therapy in complex treatment of duodenal ulcer, and the mechanisms of its action

 2006;84(7):35-41.

The effectiveness of SCENAR therapy in complex treatment of duodenal ulcer, and the mechanisms of its action

[Article in Russian]

Abstract

A new technique of low-frequency modulated electric current therapy, SCENAR therapy, was used in treatment of 103 patients with duodenal ulcer (DU). The influence of SCENAR therapy on the main clinical and functional indices of a DU relapse was studied. It was shown that SCENAR therapy, which influences disturbed mechanisms of adaptive regulation and self-regulation, led to positive changes in most of the parameters under study. Addition of SCENAR therapy to the complex conventional pharmacotherapy fastened ulcer healing, increased the effectiveness of Helicobacter pylori eradication, and improved the condition of the gastroduodenal mucosa.

THE EFFECTIVENESS OF SCENAR BIOFEEDBACK TRANSCUTANEOUS ELECTRONEUROSTIMULATOR IN TREATMENT OF BURN PATIENTS

Published in: “Emergency Medical Aid” – Russian research and practice journal, 2006, volume 7, No.3 – p. 138.

Authors: Yurova Y.V., Tarakanov A.V. Research and development institute of emergency medical aid “I.I. Djaneridze”, St. Petersburg, Russia.

Title: The effectiveness of SCENAR biofeedback transcutaneous electroneurostimulator in treatment of burn patients

Key words: SCENAR therapy, burns, analgesia

Annotation: Results of analgesic effect of therapy with SCENAR in 40 patients with II – III B-degree burns, combined with non-narcotic analgesics is compared with the effect of analgesics as monotherapy. A description of the methods of SCENAR-therapy is given for this category of patients. The authors come to a conclusion that in combined therapy the analgesic effect occurs faster and it is more durable.

THE EFFECTIVENESS OF SCENAR BIOFEEDBACK TRANSCUTANEOUS ELECTRONEUROSTIMULATOR IN TREATMENT OF BURN PATIENTS

Self-controlled energoneuroadaptive regulator SCENAR is designed for therapeutic non-invasive actions with use of electric impulsive current on cutaneous covering and human mucosae aiming to perform general regulatory effect on body’s physiological systems for wide range of pathologies, directing body’s reactions to restoration of impaired functions and to activate body’s resources. Researches made in recent years have found out that biological influence of impulsive effect includes various phenomena referring to the impact of the active factor on morphological and functional condition of the tissues and intracellular metabolism. High-amplitude electric signal has a severe impact which activates nerve fibers with no deleterious effect due to its short continuance.

Research objective

Defining the analgesic effect of SCENAR therapy in burn patients with combined therapy of non-narcotic analgesics, compared with the effect of non-narcotic analgesics as monotherapy.

Materials

The research was performed in 40 patients (13 men and 27 women), who were being treated in the Thermal damage Unit at the research and development Institute of Emergency Medical Aid “I.I. Djaneridze”. Patients with scalds – 23, with flame burns – 15, contact burns – 2. The control group of 23 patients was only prescribed non-narcotic analgesics as analgesic treatment, 10 minutes after bandaging. The primary group of 17 patients was prescribed a combination of the above-mentioned analgesics and SCENAR-therapy.

Methods

In II-degree burns the device’s electrode was applied onto the bandage directly on the burnt area. SCENAR processing was performed during bandaging at the burn periphery in patients with III-A –III –B degree burns. When the bandages were applied, the intact symmetric cutaneous areas were processed with SCENAR in the modes of “Swept Frequency”, and ‘Comfort Effect”. Subjective sensations in the areas of the burn wounds were controlled in all patients before and after the procedure for two days (till the next bandage application).

Research findings

When a combined analgesia was used, the analgesic effect could be noted in 5 patients in 10 minutes; 10 patients had the effect in 10-20 minutes, and in 20 minutes after the injection – in 1 patient. The duration of the analgesic effect in patients of the primary group was as follows: 5-6 hours in 11 patients; 3 hours in 2 patients; more than 6 hours in 3 patients. Following results were found in the control group: Analgesic effect with analgesics occurred as follows: 30-40 minutes in 8 patients; 1 hour in 5 patients; the duration of the analgesic effect did not exceed the limit of 2-3 hours.

The results evidenced that painful sensation was reduced in 94% of the primary group (16 patients). In the control group, where non-narcotic analgesics only were used as analgesic therapy, a sufficient analgesic effect was noted only in 56% of the patients (13 patients). 44% of the patients (10 people) asked for additional analgesic injections due to pain complaints. Idiosyncrasy to eradiated electric current when treated with SCENAR was found in 1 patient (unpleasant sensations in the affected area). One patient refused to be injected – SCENAR treatment was sufficient to eliminate painful sensations in wounds.
Thus, the produced results can be used as evidence of fast effect and prolonged action of injected analgesics in combination with SCENAR. SCENAR-therapy is effective as a combined treatment in burn patients and further research seems to be appropriate.

Analgesia With Device For Sensory Restoration

Abstracts of the 18th MASCC International Symposium

Support Care Cancer (2006) 14: 583–687 DOI 10.1007/s00520-006-0078-x

21-146
Analgesia With Device For Sensory Restoration.

Boris Zaidiner1, Ilya Baranovsky2, Alexei Dmitrenko31 City Cancer Hospital, 2Medical unit “Zdorov’e”, 3City Cancer Hospital

Background: Cancer pain relief has still some problems. In the attempt to contribute solving them, we have presented data on the usage of the new device which was designed for sensory system restoration with transcutaneous electrical stimulation; its analgesic activity was accidentally noted in some patients (pts).

Methods: Our preliminary trial was conducted in 34 pts (men 16, women 18; mean age 55.3) who had various nosologic forms of malignancies with chronic pain syndromes. As was verified, the origin of pain was caused by generalized cancer process (tumor growth and/or remote metastases) in all cases. The pts were administrated analgesic drugs with WHO recommendations but they continued to suffer from pain. After signing the informed consent these pts received additional therapeutic course which consisted of 10…15 procedures.

For the resuIts of this treatment to assess pain intensity (PI) and pain relief (PR) were recorded. PI was evaluated with categorical rating scale (CRS), its range varied from 0 (“no pain”) up to 10 (“pain as bad as I can imagine”). PR was rated
using 5-point scale; its range was from 0 (“none”) to 4 (“complete”).

Results: The average baseline CRS score was 6.1. In 23 pts of 34 (67,6%) good results were achieved: CRS < 3 and PR 3…4 with reduction of drug usage. 8 pts (23.5) had moderate results: CRS 3…5, PR 2; in 3 pts the results were bad (CRS > 5, PR 0…1). Besides pain relief depressive symptoms were regressed in 17 of 26 pts who had such disorders; this antidepressive action was confirmed with both clinical observation and data on routine HAM-D scale (?50% declining).

Conclusion: The new device is useful in cancer pain relief as a part of comprehensive therapeutic program. Its exact position here will be established in the randomized placebo-controlled study that is being conducted now.

 

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SCENAR in der Anwendung bei muskulo-skelettalen Beschwerden

The article is in German language

SCENAR in der Anwendung bei muskulo-skelettalen Beschwerden

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SCENAR AND BURN PATIENTS. MECHANISM OF ACTION IN TERMS OF THE FUNCTIONAL SYSTEMS THEORY

SCENAR and burn patients. Mechanism of action in terms of the functional systems theory.

Published in: Non-pharmaceutical medicine – 2006 – No. 4 – pp. 23-25.

Author: Tarakanov A.V. ZAO OK “RITM”, State University of Rostov-on-don; Taganrog

Key words: SCENAR-therapy, skin burns, polyparametric signal, functional system

Annotation: The article studies the effectiveness of different methods of SCENAR-therapy in 96 male patients at the age of 18 to 80 with heat injury. During the research, SCENAR was used applying 3 different methods described in the article, in three groups of patients as both combined therapy and monotherapy. Parameters of oxidative-antioxidative blood systems were studied; general clinical examinations, planimetry, and photo registration of burn wounds were performed before and after the treatment. The author suggests a hypothesis on SCENAR’s performance in heat injuries. He hypothesizes that the effectiveness of different methods of SCENAR-therapy is implemented through polymarametric signal which allows the brain to start a system of non-specific activation and makes the functional system of dermal recovering become complete and closed, respectively functioning. SCENAR-therapy also has a local multifunctional effect.

Importance of the matter. Skin as an organ developed from the same germinal layer as the brain and acts as its continuation and receptor screen which connects us with and detaches from the outside world. Dermal functions are very different: mechanical protective function, receptor (pain, sense of touch, temperature etc), thermoregulatory, respiratory, external secretory (sweat and oil glands), chromogenetic, endocrine, immune, and excrectory. Skin has energetic functions which are insufficiently explored but widely used by reflexologists in practice. Biologically active dots, interdot spaces, and spaces over the skin take part in the performance of these functions.

In terms of integral positions, the skin is a “peripheral brain” and the most intellectual body’s membrane. All the events in the body reflect as different symptoms on the skin, and vise versa! This is why, neural, humoral, and probably energetic and holographic mechanisms were created by the nature. A mechanism of self-regeneration is also genetically programmed in the skin.

The damage of the cutaneous covering caused by diseases and traumas results in deprivation of many functions. The loss of skin due to burn traumas seems to be the most dramatic one. A burn, as a mighty stress, is combined with pain, loss of plasma, contamination, and intoxication.

The analysis of the modern therapeutic methods and the materials of conferences and symposia show that methods of sanogenetic activation of body’s own adaptive abilities are rarely used. We believe that the method of SCENAR-therapy could successfully take its place in this niche (SCENAR – Self-Controlled Neuroadaptive Regulation).

Research objectives – to study the effectiveness of different methods of SCENAR-therapy in patients with heat injuries. To suggest a hypothesis of SCENAR-effect in heat injury.

Materials and methods of research
The research was made in the Heat Injure Centre of Rostov-on-Don, Burn Centre at the Research Institute of Emergency Medical Aid “I.I. Djaneridze” (St. Petersburg) and Burn Centre of Saratov.
The research was made from 2001 to 2006, and 96 male patients at the age from 18 to 80 were examined. Parameters of oxidative-antioxidative blood systems were researched, general clinical examinations, planimetry and photo registration were performed before and after the treatment.

The general scheme of SCENAR-therapy was as follows: burn surfaces and edges of the wounds were not processed with SCENAR. The treatment was performed as a combined and in some cases as an independent method. Individually and subjectively measured modes were applied. The remaining intact skin was processed using 3 different methods in 3 groups of patients.

Method 1. (Face and back which were not burn-damaged). “3 paths and 6 points” were altered every second day with the neck and collar zone, plus skin zones symmetrical to the burn wound were processed if possible [1].

Method 2. (Intact palms and plantae). Electrodes – spread, sized 3×10 cm: each manipulation was combined with processing of dermal zones located in the area of the palms (thenar, hypothenar) and the feet (the zone under the pollex in the area of regioplantarispedis) by 10 minutes each; final processing – the dermal projection of the liver – 10 minutes.

Method 3. (Affected or/and unaffected palms and plantae) Electrodes – spread, sized 3×10 cm: each manipulation was combined with processing of dermal zones located in the area of the outer medium surface of the shank, medium inside part of the forearm by 10 minutes each; final processing – dermal projection of the liver or the zone symmetrical to the burn – 10 minutes.
The course of the SCENAR-therapy consisted of 10-15 procedures every day.

Results and discussion
During the use of all SCENAR-therapy methods, improvement of clinical blood value was stated, the anti-oxidative potential (with a reliable increase of superoxide dismutase and catalysis of erythrocytes, and with decrease of medium mass molecular concentration) restored. Enhance of granulation tissue growth and boundary epithelialization was stated in singes. A manifested enhance of wound cicatrization due to its rapid cleansing was also stated.

Facts of initiated recovering process in patients with serious concomitant diseases, and the torpent, areacive course of the burn disease are an important clinical observation. During the experiment with SCENAR-therapy, a decrease of the genotoxicity of the mutagenesis in burn wounds and positive effect on proliferous tissue activity was observed [2].

A manifested analgesic effect, prolongation and potentiation of the effect of narcotic analgesics with decrease of the dose were stated [6].

It is important to note that SCENAR-therapy is a comfortable sanogenetic method of treatment. There is no need to process the burn surface or the surfaces around the burn, which is almost impossible with bandages and necrectomy [4].

To explain the effect of SCENAR-therapy in different methods of treatment, we suggest a hypothesis fitting one of the forms of the systematic approach. This is P.K.Anokhin’s functional systems theory [3,5].

Significant damage in dermal functional system (as an organ) is stated in cases of burn. This means diminution of afference, deprivation of information about the outer environment, impossibility of proper thermal exchange regulation, changes in tactile and pain sensitivity, damage in energy exchange between the body and the outer environment, decrease of the protective function, appearance of “gates” through which protein and electrolytes are lost, infection and intoxication.

Apart form this, a big wound surface causes supertension of cerebral antinociceptive system to decrease input of information from the burn wounds tissues. According to our hypothesis, a functional “denervation” of all the skin happens, and its functional rejection develops. The body and the brain stop “seeing” it. The functional system breaks down. Retarded regeneration follows, as well as soft and areactive course of the burn disease.

In this situation SCENAR acts as a system-forming receptor factor. The device generates bipolar high-voltage impulses without a constant component. The impulses change depending on the dermal condition and its corresponding internal organs and tissues on the grounds of biotechnological feedback.
A specific for SCENAR-therapy effect of dermal electrostatic vibration (return acoustic effect) is also stated. For the body, this is a permanently new, structurally changed by itself effective signal. The return afference to the brain from SCENAR is marked by numerous parameters.
Apart from an electric stimulus in itself, SCENAR-therapy includes pain, thermal and tactile excitation in its effective complex.

It is necessary to note that local mechanisms of regeneration startup exist. They function in dermal denervation, too, for example, in spinal patients. Local dermal processing around the wound would probably be successful.

The architecture of dermal functional system is a cyclic closed self-regulated organization. Its main point is the positive adaptive result: a permanent recovery of the lost elements and performance of its specific functions. Deviations from the result are perceived by the receptors. In burn wounds they do not exist, they are destroyed.

Thus, SCENAR eliminates afference diminution, sends signals to the nerve centres about the remaining unaffected skin, gives non-coded unrecognized information through its polyparametric signal. This allows the brain to start a system of non-specific activation, and gives a targeted signal through specific zones (Su-Jock method) and through biologically active points, and gives a local multifunctional effect. SCENAR-therapy makes the functional system of dermal restoration become close, hence active.

Bibliography
1. Gorfinkel Y.V. Theoretical and practical bases of enhanced effectiveness of SCENAR-therapy//SCENAR-therapy and SCENAR-expertise: compilation of articles – No. 2, Taganrog, 1999, pp. 16-18
2. Makletsova M.G., Grinberg Y.Z. Mirzoyan A. and others, Influence of SCENAR-processing on the level of chromosome aberrance and mitotic index in eye cornea, bone marrow and rats’ testicles after burn traumas//SCENAR-therapy and SCENAR-expertise, compilation of articles, – No. 8, Taganrog, 2002, pp. 26-30.
3. Introduction to the physiology of functional system/ Edited by Sudakov K.V. – M.: Medicine, 1983 – p.272.
4. Tarakanov A.V., Grinberg Y.Z., Egorova O.A., Mlyutina N.P. Possibilities of early rehabilitation in burn patients with use of SCENAR-therapy// Emergency Medical Aid, 2006 – No.3 – pp. 250-251.
5. Functional System of the body: instruction/Edited by Sudakov K.V. – M.: Medicine, 1987, – p. 432.
6. Yurova Y.V., Tarakanov A.V. Effectiveness of the transcutaneous electroneurostimulator with feedback (SCENAR) in burn patients // Emergency Medical Aid, 2006 – No.3, p. 138

 

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Modern Therapies for burn wounds

Published in: “Emergency Medical Aid” – Russian research and practice journal – 2006, volume 7, No. 3. – pp. 133-134.

Authors:  Kharitonov S.A., Korolyov V.A., Tarakanov A.V. Burns centre, State Medical University, Rostov-on-Don, Russia.

Title:   Modern Therapies for burn wounds 

Key words:  SCENAR therapy, burns.

Annotation:  Modern therapies for burn wounds are described in the article. Methods of sanogenetic activation at all stages of treatment are noted as promising and advanced, as well as the achievements of modern technologies based on biotechnological response which made it possible to create devices with real lack of adaptation period to excitation, which causes response reactions directed to enhance body’s restoration. According to the author, the method of SCENAR-therapy is the most multifunctional and procurable in current conditions. For the purposes of therapy, this method allows us to use cutaneous covering and mucosae which were not affected by burning injuries.

MODERN THERAPIES FOR BURN WOUNDS

Burn treatment is one of the most complicated, labour-consuming and expensive processes in practical medicine, which requires theoretical knowledge and practical skills in various areas of surgery, critical care medicine, traumatology, therapy, microbiology, biochemistry. This specifically concerns deep burns of III B – IV degree, which are treated in hospital only, because skin grafting is necessary for restoration of the cutaneous covering. To enhance wound detersion from necrotic tissues surgical and chemical necrectomy is performed with one-stage or delayed skin grafting.

At different stages of the wound process, local burn treatment aims different objectives. At the first stage of eschar rejection, inflammation and abscess, local treatment is directed to resist infection and to enhance rejection of necrotized tissues. Wet-to-dry dressing with solution of iodophors active to gram-positive and gram-negative bacteria, fungi and viruses, is used to form dry eschar. Wet-to-dry dressing with other antiseptic solutions are traditionally used – chlorhexidine, dioxidin, furacilin (nitrofurazone), miramistin and others.

Methods of physical action are used to dry wounds – fluidizing beds, infrared irradiation, controllable abacterial environment, laminar air flow (LAF) rooms etc. Unctures are used to inhibit pyoinflamamtory process, which is effective for the wounds’ microflora. Polypharmaceutical ointments with water-soluble (hydropilous) base and silver bearing ointments have become popular in Russia. At the second stage of the wound process – the regeneration – after eschar rejection local conservative treatment should be directed to create good conditions of granulations maturation and to prepare the wound for skin grafting. There are now data of more than 300 wound coverings at different stages of research and development. Nevertheless, a multifunctional drug which could be used at all stages of the wound process of different depth of burns still does not exist.

Drugs containing natural polymers, such as collagen, polysaccharides, cellulose etc. were used to stimulate granulations growth. Synthetic films with or without micropore made of polyurethane, polypropylene, polyethylene, polyvinyl chloride etc. became widely used to close burn wounds.

Cutaneous covering restoration through skin grafting is performed after exsection of burn wounds to the level of viable tissues or preparation of granulation tissue. Along with erasion of necrotizing tissues and reduction of bacterial content of the wound, preparation for plastic closing in burn disease should also include correction of body’s overall condition. If these are not performed, decline in the course of the reparative process in the wound can be expected, which will negatively affect the skin grafting.

One of the most serious problems of major burns treatment (more than 15-20%) is impossibility of single-step closing of the burn wound with autografting, due to shortage of donor resources. The problem of donor shortage can be solved by using modern biotechnological methods – grafting of cultivated cells of human derma (human dermal fibroplast, keratinocyte), living dermal equivalent, cultivated dermal substitute. Dermal allograft is taken form human cadaver, from still-born children, “junk” skin after amputation. Sking grafts usually vascularize (and survive) by the 3-5th day of the allotransplantation on adequately prepared wound’s bed. Then a rejection of dermal allograft occurs in about 2 or 3 weeks on average.

Taking under consideration legal and other difficulties of procurement and use of dermal allograft, we consider perforated suilline xenoderma as the best solution for the purposes of temporary biological covering. Moreover, research and use of cultivated human dermal cells and cultivated skin substitutes for the purposes of closing major wound surfaces is a promising and advanced theoretical and practical approach.

Methods for activation of sanogenesis at all stages of treatment should also be advanced. Modern technologies based on biotechnological response made it possible to create devices with real lack of adaptation period to excitation, which causes response reactions directed to enhance body’s restoration. The method of SCENAR-therapy is the most multifunctional and procurable in current conditions. This method allows to use cutaneous covering and mucosae which were not affected by burn injuries.

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THE CENTRAL EFFECT OF THE SCENAR-THERAPY, SELF-RESTORATION OF THE ORGANISM BY THE ACTIVATION OF THE FRONT HYPOTHALAMUS

Chebcasov S.A. Bereshpolova J.I. (Rostov-on-Don)
THE CENTRAL EFFECT OF THE SCENAR-THERAPY, SELF-RESTORATION OF THE ORGANISM BY THE ACTIVATION OF THE FRONT HYPOTHALAMUS

Taking into account the known biological and physiological laws and also the peculiarities of the Scenarinfluence,
it would be natural to suppose that together with the described above peripheral effect, which isdetermined by the secretion of the biologically active substances [1], Scenar must render and the central influence which mobilizes the regulating mechanisms of the self-recovery system of the organism[2].

It could be connected with the moments of synchronism of the brain electrical activity with the leading role of the anterior parasygmatic hypothalamus, which coordinates the activity of the vegetative system in the mode of self restoration [2].

The aim of this work is the experimental testing of the hypothesis, given above and the search of the possible ways to strength the central effect of the Scenar stimulation. As the direct research of the intracerebral structures activity isn’t ethical, and mammals nervous system including the human beings, has very much in common, the research of the central effect was began on the animals with the prospect of usage of the received results in people treating. One of the main tasks was the working-out of the Scenar- stimulation effectiveness criteria.

There were 8 sharp experiments, carried out on the guinea pigs and 12 experiments, carried out on the sleepless rabbits. The electrodes were implanted into the structures of the anterior and the posterior hypothalamus. Cortical leads were carried out from the brain surface, epidermal from the somatosensory and
visual areas. Scenar-influence was carried out, mostly, on the shoulder surface with the frequency of 59,3 Hz.

Pic.1


For the study of the central effect of the Scenar influence the 30-minutes stimulation was used. We found out the increasing of the power of the oscillations in the low frequencies area and the obvious tendency to the development of generalized activity on every lead at the time of irritation and after it. During that in the electrogrames of the guinea pigs the alpha–like spindles (pic 1a) was observed, and in the electrogrames of the kept- awake rabbits, there were, beside that, the outbursts of the oscillations in the sigma rhythm and the appearance of the K-complexes (pic.1b).

Such forms of activity, as it is known, are revealed during the sleep with its heightened tone [3].
Behavioral reaction of the animals is also the evidence of the paradigmatic tone increase. The animal stops to hold the head (weakening of the antigravity muscles), behaves calmly, eyes fall behind (endophtalamitis is the clear sign of the increasing of the parasympathetic tone).

The examples of the electrograme registration of the brain structure of the guinea-pig: A)1,2–Visual cortex; 3,4–somatosensory cortex; 5,6? the anterior hypothalamus; 7,8? the posterior hypothalamus.
B) 1,2- Visual cortex; 3,4 somatosensory cortex; 5,6 the posterior hypothalamus;7,8- the anterior hypothalamus.

Pic2.
The analysis of the Scenar-stimulation effect development on the spectrums of power regularly showed the increase of the slow-wave oscillations in all investigated leads. In some cases the maximum synchronization was observed in 15 minutes but more often it was developed during the first 15 minutes of the stimulation.(pic.2b.c.).

The repetition of the appearance of the generalized synchronization from the experience to the experience is the evidence of the regularity of this event (p<0,01, the criterion of the signs) as the result of the Scenar-influence.

Thus, the main electrtographic effect is revealed in the generalized slow-wave activity of the brain structures.

The examples of the activity development dynamics in the brain structures at the prolonged Scenarstimulation, traced on the spectrums of the power for the guinea-pig(A) and the rabbit(?)–shoulder,(?)-the head against the background(I), 1,5 minutes after having the influence(II), 15 minutes after having stimulation(III), 30 minutes after having stimulation (IV) and then (V) 1–visual cortex; 2?somatosensory cortex;3?anterior hypothalamus;4?posterior hypothalamus.

The peculiarities of the Scenar influence on the different areas of the brain lied in the fact, that the synchronization was better pronounced for the anterior hypothalamus then for the posterior and for the visual cortex than for the somatosensory cortex. Such results could be observed and afterwards. At that, as it was cleared up during the additional treatment of the materials the earliest signs of the synchronization are observed in the somatosensory cortex. The fact of the more pronounced activity of the anterior parasympathetic hypothalamus in comparison with the posterior one sympathetic is the evidence of the leading role of the first one and denotes the increasing of the parasympathetic tone under the influence of the Scenar therapy.

High co-ordination of the activity changes in the visual cortex and in the anterior hypothalamus was found. It turned out to be that the activity of these structures is highly correlated for the rabbits and for the guinea pigs as well In general taking into account the extracts P<0,001.

The marked fact let us judge about the increasing of the anterior hypothalamus activity (the growth of the parasympathetic tone) on the indices of the synchronized activity of the visual cortex and could be used as the criterion of the Scenar-influence effectiveness and also in the EGG researches.

The fact of the major reaction of the visual cortex, instead of the somatosensory after the electroskin irritation is paradoxical on the face of it. But it should be taken in account, that we observe the already developed systemic effect of influence, which covers many structures of brain. It goes without saying that the center of the activity, created by the Scenar- stimulation appears primarily in the somatosensory cortex. This causes the activation of the synchronizing system with its important unit–the anterior hypothalamus. The anterior hypothalamus, in its turn, as it appears from the results, and as it was proved by N.V.Suntsova [4] for other animals, causes the generalized synchronization, characterized by high correlation in the field of the alpha-like oscillations for the anterior hypothalamus and the visual, but not somatosensory cortex. The increased activity of the anterior hypothalamus, determining the increase of the parasympathetic tone stimulates alpha-activity and after that.

This fact deserves a special attention. According the Garcavy’s researches [5] such electro?physiological picture is the correlate of animals and people anteaters reaction training With its very development the researchers pin the important sanitary consequences, in particular, the treating effect of the Scenar device.

Taking into account all the data given in the literature, our results show that the development and keeping afterwards the increased alpha-like activity in the visual cortex, especially after the Scenar-stimulation (pic 2,A,B,C,) can be regarded and as the criterion of the Scenar influence effectiveness and as pointing out on the parasympathetic nature of these reactions.
It’s known that the stimulation of the skull skin, which is characterized mostly by the parasympathetic innervation [6], has very good medical consequences. The irritation of the head’s skin (pic2B) with the help of the 24 needle electrode is characterized by a greater synchronization of the activity then when with the help of the same electrode the skin of the shoulder is treated. Let’s note the fact, that when skull skin of the rabbits was stimulated, they looked like sleeping?they closed their eyes.

This fact points out a considerable increase of the parasympathetic tone. After such stimulation the increased slow-wave activity (parasympathetic tone) can be stored 24 hours after the Scenar treatment.

The role of the synchronization of the slow?wave activity created by the Scenar on the analogy of that, during the state of sleep, can be connected with the easing of the access to the information about the “inner body” of the organism to the screen of the cortex, keeping the “standard of the healthy body” in it. A very important demand for this standard?the stability of the organization?is provided by that fact, that the cells of the brain cortex, unlike other cells of the body, are not replaced by the new ones during the life cycle.

Under the conditions of the active staying awake, which is characterized by the desynchronized activity of the brain structures and high sympathetic tone, the cortex of the brain, as is well known, is unavailable or is available only for the very powerful signals from the inner organs. The different matter is the state of the sleep when there is a high synchronized activity (and parasympathetic tone) [3,7,8].

Similarly in one’s sleep generalized synchronization, created with the help of Scenar influence, makes it possible, that the signals about the state of the “inner body” of the organism can reach the cortex. It also gives the opportunity of the making of the corresponding correcting signals to the intermediate control levels and executive structures. Among them the structures of the front hypothalamus, changing the work of the vegetative system to the mode of the recovery, have the particular role. At that, because of the activity focus, created by the Scenar from the corresponding zones of the small asymmetry, the localization of the affection center is pointed out .Such condition is not the state of sleep, when the generalized activity is very probable. But the sleepy condition, developing, according the clinicians at the effective Scenar influence, is the evidence of the essential similarity of the concerned states .It is proved and by the introspection.

The general scheme of the Scenar influence, in the light of the carried out research (which showed and primordial increase of the synchronized activity in the somatosensory cortex ), may be shown this way. The centers of the activity, created with the help of the Scenar influence, in the somatosensory cortex I and II, through the lemniscus and extralemniscus systems, and also, maybe, straight influences on the hypothalamus on the spinothalamic canal, actives the synchronizing system of the brain with the front, parasympathetic, hypothalamus. The front hypothalamus, in its turn, supports the general synchronization of the cortex and of the subcortical structures, especially over the range of the alpha rhythm in the visual cortex. Under these conditions the sections of the brain, keeping the standard of the healthy “inner body” in them, become
available for the signals from all the inner organs, and among them-the increased with the help of the Scenar influence signals from the hearts of the pathology. ”Checking” of the organism state condition with the standard provides with the working out of the corrective signals, correlated with the state of the whole organism. These corrective signals, directed on the self-restoration are signals to the levels of the.

Intermediate control, most of all to the front parasympathetic hypothalamus and to the executive systems. The achievement of the aim effort is provided with the help of secretion/isolation of the according biologically active substances[1].

As an aftereffect the increased activity of the front hypothalamus is reflected in the according increasing of the alpha-activity of the brain cortex, especially of the visual area. I.e. if there is the sufficient parasympathetic tone, which reflects the activity of the organism, concerning its self-restoration, the increasing power of the alpha activity must be observed in the cervical leads. This is observed as the aftereffect of the Scenar-theraphy.

The results of the comparison of the Scenar-influence on the shoulder and head areas which follows our research let us to speak about the ability of the increasing the Scenar-influence effect with the help of the combined use of the electrodes.

One of the electrodes, the broad one should be placed in this or that area of the increased parasympathetic innervation-the surface of the head, the sacral, the erogenous areas. With the help of the broad electrode the general increasing of the parasympathetic tone is achieved. Another electrode, the remote one is used, as usual, on the according areas of the small asymmetry. This electrode points to the “address” of the according pathology.

We investigated the effect, emergent at the combined influence of the electrodes on the symmetrical areas.

It turned out to be that such kind of stimulation can reduce to the more pronounced effect (pic3).

The combined effect of the narrow and broad electrodes from the symmetric areas of the skin surface (shoulder) causes the synchronizing effect at the 2-minutes’ stimulation: 1?the visual cortex; 2?the somatosensory cortex; 3?the anterior hypothalamus; 4?the posterior hypothalamus; I-before, II-against a background of stimulation, III-in aftereffect.

Thus, it seems to be expedient to carry out the clinical tests with the application of the external Scenar electrode.

Taking into account the picture of the aftereffect, revealed during the researches ,it seem to be possible to carry out the successive usage of the broad and external local electrodes?first the broad one on the zones of the high parasympathetic innervation and then (against a background of developed parasympathetic tone) external on the areas of small symmetry.

LITERATURE.
1. Grinberg Y.Z. the effectiveness of Scenar-therapy. Physiological aspects. //In “Scenar-therapy”, ”Scenar-expertise” collections of articles. Taganrog, 1998, issues 4-8.
2.Chebkasov S.A. Health strategy. The system of structures outstripping self-restoration. The problem of parasympathetic vegetative system activation. Valeology.2000. ?1 p. 80.
3.Karmanova I.G. –What we know about the cycle “staying awake condition-sleep condition” and the reasons of its disorders. St.Peterburg.1998. p. 93.
4.Suntsova N/N/ The anterior brain mechanisms of the sleep development.//Submitting for dissertation for the doctor’s degree. Rostov State university, Rostov-on-Don,2000, p.372.
5.Garkavi L.N. and others. Antistress reaction and activation therapy, M:IMEDIS,1998, p.656.
6.Luvsan Gavaa.Traditional and modern aspects of eastern medicine.M,1992, p.576.
7.Danilova N.N. Psychophysiological diagnostics of functional states, M,1992, p.192.
8.Nozdrachev A.D. and others. General course of human and animals physiology. //BookII Physiology of visceral systems. M,High school,1991, p.6-28.

Benefit in patients with knee osteoarthritis through adjuvant electro auricular acupuncture vs. Manual body stimulation with self-controlled energo neuro adaptive regulation (SCENAR®™)

EFIC5-1157 Late-breaking Poster Sessions, 9th Congress of the European Pain Federation, Vienna, 2015

Benefit in patients with knee osteoarthritis through adjuvant electro auricular acupuncture vs. Manual body stimulation with self-controlled energo neuro adaptive regulation (SCENAR®™)

R. Schukro1 , I. Mandl-Krusche2 , A. Kaider3 , S. Sator-Katzenschlager4
1 Special Anesthesia and Pain Therapy, Medical University of Vienna, Vienna, Austria

2 Dept. of Trauma Surgery, Medical University of Vienna, Vienna, Austria

3 Center for Medical Statistics Informatics and Intelligent Systems, Medical University of Vienna,Vienna, Austria

4 Dept. of Special Anesthesia and Pain Therapy, Medical University of Vienna, Vienna, Austria

Introduction: Knee osteoarthritis (OA) is a major cause of knee pain. Alternative approaches such as electrical auricular acupuncture (EAA) are gaining importance. Another alternative treatment aiming to reduce pain is Self Controlled Energo Neuro Adaptive Regulation (SCENAR®™).

Methods: 46 patients were randomized to the EAA group (n=15), to the SCENAR group (n=14) and to the control group (n=15). Amount of rescue medication, pain intensity (NRS), range of motion (ROM) in the sagittal plane and the pain free walking distance in minutes as well as knee function assessment were evaluated on study day 1, 42 and 70.

Results: Comparing the rescue medication after baseline therapy no significant difference was found between the three groups (p=0,86). In the control group we found a median of 1 [Q1 25%=1; Q3 75%=2], in EAA group a median of 0 [Q1=0;Q3=3] and in the Scenar group a median of 0
[Q1=0;Q3=3]. Highly significant differences of amount of rescue medication were found on day 42 and 70 comparing EAA group and control group (p<0,001), as well as in the Scenar group compared
to the control group.

Conclusion: The results of this study show that EAA and Scenar in combination with medical analgesic treatment are superior to medical analgesic treatment alone. Pain relief was maintained one month after the therapy was discontinued in these two complementary methods. Further studies are necessary to evaluate long lasting effects in knee OA.

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SCENAR-therapy effect on the state of the blood plasma redox balance in patients with organ ischemic injury

Reflexology. – 2005 – N3(7). – pp. 37-42.

SCENAR-therapy effect on the state of the blood plasma redox balance in patients with organ ischemic injury

L.V.Klimova, A.V.Tarakanov, A.V. Kartasheva, N.N.Usalyova

Emergency Department, Rostov State Medical University (Rostov-on-Don)
Clinical Trials Department, RITM OKB ZAO (Taganrog)
Emergency Hospital N2 (Rostov-on-Don)

Ischemia and postischemic disorders will always be of current importance in medicine. A large group of diseases, where disturbed circulation or no circulation in the organ or tissue is  one of the main pathogenic trigger, includes such severe diseases as acute myocardial infarction (AMI) and acute renal failure (ARF) caused compression injury [1,7].

Ischemia is the trigger element for a number of processes that inhibit the cell functionality at first stages thus helping them to survive in sudden oxygen deficiency. With the tissue reperfusion – restoration of the blood flow – cell injury may continue because of so called oxygen paradox caused by increased production of active oxygen forms and activation of lipid peroxidation (LOP) under these conditions. But reperfusion is the “necessary evil” [4]. The sooner it happens – the less permanent the damage is. In today’s medicine mechanisms of reperfusion injury are called oxidative stress, which changes the redox balance (prooxidant – antioxidant balance) in the body and shows as accumulation of LOP toxic products and compensatory change in component activity of antioxidant system [1, 2, 5, 6].

Today many researches investigate the process of oxidative stress in patients with Q-wave AMI and ARF caused compression injury, when SCENAR-therapy is included into the multiple therapy [3, 8]. They prove that in comparison with other methods multiple therapy with SCENAR-therapy gives better clinical results due to arresting of the oxidative stress phenomena. We decided to continue investigations and find out is there any specific SCENAR-therapy effect on the oxidative stress in patients from the two groups.

Research objective

Investigate is there any specific SCENAR-therapy effect on the state of the blood plasma redox balance in patients with Q-wave AMI and ARF caused by compression injury.

Research task

Compare initial level and dynamics of primary, secondary and final LOP products in the blood plasma of patients with the indicated pathology: conjugated dienes (CD), malondialdehyde (MDA) and schiff bases (SB), as well as catalase (CA) and ceruloplasmin (CP) activity.

Materials and methods

Considering the research tasks and objectives we compared biochemical blood indices in both groups where patients were given standard treatment complemented with skin stimulation using SCENAR-97.4.

I group – 17 patients with ARF caused by compression injury.

The patients were treated using one of the two general stimulation methods: “3 pathways and 6 points” and “collar zone, forehead, adrenals” in the subjectively dosed mode (SDM). The treatment course started on patient’s admission to the Acute Hemodialysis Department and included 10 daily sessions. The blood samples for biochemical tests were taken on admission and on the 1-2 day of diuresis recovery. It should be noted that average anuretic period in this group was 11.3±1.3 days.

II group – 30 patients with Q-wave AMI that had contradictions to thrombolytic therapy.

In these group patients were treated using one of the two general stimulation methods: “3 pathways and 6 points” and “collar zone, forehead, adrenals”. Stimulation of the standard treatment zones was complemented with stimulation of heart zone (5-10 min) and pericardium meridian points (PC4, PC6 and PC7) on both arms (2-3 minutes). The treatment course included 10-14 daily sessions and started at the very first day of the disease. The blood samples were taken on admission and on the 16 day of treatment.

The quantity of conjugated dienes (CD) was determined  pectrophotometrically using I.D. Stalnaya method (1977). The content of malonic dialdehyde (MDA) was measured by M.D. Stalnaya  and T.D. Gorishvili method (1977). To determine Schiff Bases (SB), lipids were extracted from plasma using the Bligh-Dyer method (1959). Catalase activity (CA) in the blood plasma was determined using M.A. Korolyuk et al. method (1988). The oxidase activity of ceruloplasmin (CP) was determined using the Revin’s method adapted by V.G.Kolba and V.S.Kamyshnikov (1982).

Indices of patients in both groups were compared with the indices of almost healthy donors-volunteers.

Results and discussion

The content of LOP products and activity of blood plasma enzymic antioxidants in patients with ARF caused by compression injury before and after multiple treatment complemented with SCENAR-therapy are given in the Table 1.

Table 1

Dynamics of LPO products and activity of blood plasma enzymic antioxidants in the patients from I group

Index Donors,

n =20

ARF patients,

(n=17)

Before treatment After treatment
Conjugated dienes,

nmol/mL

13.69±1.08 20.54±2,71 (+50.0%)

?<0.05

14.00±11.90 (+2,3%)

?>0.1; 0.05<?1<0.1

Malonic dialdehyde,

nmol/mL

27.97±2.16 40.58±2.13 (+45,1%)

?<0.01

33.05±2.04 (+18.2%)

0.05<?<0.1; ?1<0.05

Schiff bases,

arbitrary unit/mL

1.41±0.06 1.88±0.10 (+33.3%)

?<0.01

1.58±0.07 (+12.1%)

0.05<?<0.1; ?1<0.05

Catalase,

nmol ?2?2/ mL

16.31±1.24 12.79±1.35 (-21.6%)

0.05<?<0.1

16.05±1.25 (-1.6%)

?>0.1; 0.05<?1<0.1

Ceruloplasmin,

?mol/L

1.31±0.08 0.72±0.09 (-45.0%)

?<0.01

1.08±0.09 (-17.6%)

0.05<P<0.1; ?1<0.05

Note: p – significance of change as compared with donors;

p1 – significance of change as compared with initial values;

numbers in parentheses show the percentage of the index change

as compared with donors;

The table shows that on admission I group patients had essential disbalance in the redox balance of the blood plasma manifested as essential hypernorm of the CD, MDA and SB content by 50.0%, 45.1% and 33% respectively. Activity of blood plasma enzymic antioxidants was low: CA by 21%, CP by 45%. It should be noted that such a decrease in CA activity was not so significant (0.05<p<0.1), while in CP activity it was really significant.

As a result of multiple treatment complemented with SCENAR-therapy by the time diuresis recovered the correlation of free radical LOP intensity and AOS activity changed. Positive dynamics manifested as decrease of MDA, SB and CP activity if compared to the initial values was statistically true (p1<0.05); decrease of CD and CA activity was almost true. Comparison of these indices with the conventional norm showed that CD and CA activity reached it, while MDA, SB and CP activity became closer to the conventional norm. In the very end CD, MDA and SB indices were 2.3%, 18.2% and 12.1% above norm respectively. CA activity changed not so significantly – it increased just by 1.6%, while CP activity increased significantly, but still was 17.6% below the norm.

The level of LPO products accumulation and activity of blood plasma antioxidants in patients with AMI before and after multiple treatment complemented with SCENAR-therapy are given in the Table 2.

Table 2

Dynamics of LPO products and activity of blood plasma enzymic antioxidants in the patients from I group

Index Donors,

n =36

ARF patients,

n=30

Before treatment After treatment
Conjugated dienes,

nmol/mL

12.4 ± 1.7 29.6 ± 1.9

?<0.001 (+138.7%)

23. 7 ± 1.8 (+91.1%)

?<0.001; ?1< 0.05

Malonic dialdehyde,

nmol/mL

20.9 ± 1.6 47.6 ± 1.7

?<0.001 (+127.8%)

44.4 ± 1.5 (+112.4%)

?<0.001; p1 > 0.1

Schiff bases,

arbitrary unit/mL

1.06 ± 0.09 1.65 ± 0.13

?<0.001 (+55.7%)

1.09 ± 0.07 (+2.8%)

p>0.1; ?1<0.005

Catalase,

nmol ?2?2/ mL

17.30 ± 1.37 14.50 ± 2.20

p>0.1 (-16.2%)

10.23 ± 1.04 (-40.9%)

?<0.001; 0.05<p1<0.1

Ceruloplasmin,

?mol/L

1.08 ± 0.08 1.40 ± 0.11

p<0.05 (+29.6%)

1.41 ± 0.09 (+30.6%)

p<0.05; ?1>0.1

Note:  p – significance of change as compared with donors;

p1 – significance of change as compared with initial values;

numbers in parentheses show the percentage of the index change

as compared with donors;

In II group patients the content of all LPO products before treatment was significantly (p<0.001) above the control values: CD – by 138.7%, MDA– by 127.8% and SF – by 55.7%. Moreover changes in antioxidant system functionality were detected. Blood samples before treatment showed that in patients’ blood plasma CP oxidative activity increased by 29.6%, while dynamics of CA activity was not significant if compared to the control values.

Complementing standard therapy with SCENAR-therapy significantly helped to inhibit intensity of all LOP stages. That was showed as decrease of blood plasma molecular products. The CD level decreased significantly, but still was above the control values by 91.1%. The tendency of MDA dynamics was the same and after the treatment still was 112.4% above the control values. The most evident and intense effect of multiple therapy complemented with SCENAR-therapy was on toxic final LOP products, SB level by the end of the treatment course didn’t significantly differ from the donor indices. High level of CP oxidative activity still remained by the end of the treatment course and was 30.6% above the conventional norm. CA activity during the treatment decreased by 40.9% if compared to the normal values, but if compared to the initial values only insignificant decrease was registered.

The indices of CD, MDA and SB in the blood plasma in patients with ARF caused compression injury and in patients with AMI before and after the treatment (percentagewise compared to conventional norm) are given in the Diagram 1.

Diagram 1

Dynamics of CD, MDA and SB indices in the blood plasma of both groups

The Diagram 1 shows that before the treatment LOP products of the testees were significantly high. The multiple therapy complemented with SCENAR-therapy caused decrease in the accumulation of primary, secondary and final LOP products.

Dynamics of activity of the blood plasma CA and CP in patients from both groups after the treatment (percentagewise compared to conventional norm) is given in the Diagram 2.

Diagram 2

Dynamics of CA and CP activity in the blood plasma of both groups

 

It was already stated above that catalase activity of the II group patients before the treatment didn’t differ significantly from the conventional norm, only in ARF patients it tended to decrease. It should be noted that essential part of the catalase pool localizes in erythrocyte cytoplasm. In extracellular water it becomes inactive very soon. Increase of CA in the blood plasma can sign that it has released from the erythrocytes as a result of pathologically high membrane permeability or even their destruction [6]. Moreover, this index characterizes utilization rate of hydrogen peroxide in the blood plasma and its decrease during the treatment. That is registered in AMI patients and can be explained as result of generation decrease of active oxygen forms under the influence of the treatment. In the group with ARF patients no significant therapeutic effect on the catalyze activity was registered.

As against to CA, dynamics of CP activity differed significantly in the groups. In I group patients CP activity was 45% lower if compared to the donor values, and in the II group it was 29.6% higher. Such a difference in values can be explained by the period of time the disease aroused. Let’s make it clear. It is known that CP refers to proteins of acute phase and activity decrease in inflammation or after the injury, on one medical evidence by 2-3 times and on another by 30-60%, is considered as compensatory reaction directed to preserve plasma antioxidant potential and maintain copper and zinc metabolism at the optimal level [6]. This reaction was registered in patients with AMI at the very first days of the disease. In patients with compression injury ARF developed in some days after the injury, that’s why by the moment SCENAR-therapy was included into the treatment and blood samples for biochemical indices were made oxidative stress was more intense and manifested in deterioration of plasma capacity, in particular in decrease of CP activity.

The diagram shows that the therapeutic effect on the CP activity in the groups was different. As a result of multiple therapy complemented with SCENAR-therapy in patients with ARF low activity of blood CP significantly increased, while in patients with AMI high activity of main plasma oxidant didn’t change, i.e. compensatory activation of this antioxidant preserved, thus preserving antioxidant capacity of the blood plasma.

Findings

  1. At the very first days of the disease patients with ischemic organ injury, in particular Q-wave myocardial infarction and acute renal failure caused by compression injury, have oxidative stress, which makes the redox balance of the blood plasma disordered.
  2. Comparing the effect of multiple treatment complemented with SCENAR-therapy on the oxidative stress in patients from both groups we detected:
    – universal effect of inhibiting high activity of lipid perioxidation in blood plasma, which manifests as decrease in LOP molecular products accumulation.
    – regulating effect on the influence on the state of antioxidant system activity of blood plasma.

 

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Pathogenetic Principles of SCENAR-therapy in Multiple Therapy of Duodenal Ulcer

Translation from Russian to English Language

Publication: Reflexology Journal, Issue No: 3 (7), 2005, pp. 43-47

Authors: Kochurova I., Cimmerman I., Vladimirsky E. Perm State Medical Academy, Department of faculty therapy, clinical pharmacology, physiotherapy and traditional methods of treatment

Article name: Pathogenetic Principles of SCENAR-therapy in Multiple Therapy of Duodenal Ulcer

Key words: SCENAR, gastroenterology, duodenal ulcer

Summary: We tried one of the new physical methods based on low-frequency pulse electrotherapy – SCENAR-therapy – as an alternative opportunity of duodenal ulcer management as it normalizes disturbed mechanisms of the body’s adaptive regulation and self-regulation. The influence of SCENAR-therapy on the clinical and functional gastric index of 72 duodenal ulcer patients was studied. Positive SCENAR-therapy effects were revealed in the majority of the patients. The combination of the conservative drug management and SCENAR-therapy shortens ulcer healing, promotes eradication of Helicobacter pylori, and improves the condition of gastro duodenal mucous.

Pathogenetic Principles of SCENAR-therapy in Multiple Therapy of Duodenal Ulcer

Nowadays SCENAR-therapy is in common practice in physiotherapy. SCENAR-therapy is a sort of low-frequency impulse electrotherapy and can be referred to the methods of reflex anesthesia (as the methods of electro acupuncture and transdermal electric stimulation of nerves). Their analgetic effect is connected with activation of endogenous antinociceptive system. Today, we’ve got various arguments of participation of antinociceptive transmitter systems in the mechanisms of reflex anesthesia [11]. The role of opioid, serotonin and noradrenergic systems in realization of reflex analgesia is proved here (F.Cervero, 1995). For treatment procedure conduction by these methods is recommended to choose areas, which are reflexively connected with sickly areas for the purpose of activation mechanisms of segmental inhibition, and also to influence on zones, which are distant from sickly area, for mobilization of central antinociceptive processes.

Parallel with peripheral effect, which is determined by peripheral of biologically active substances [6], the SCENAR-therapy method has central effect, mobilizing regulative mechanisms of system of organism recovery [27]. In many respects, it’s connected with the episodes of brain electrical activity synchronization at the leading role of forward hypothalamus, which coordinates the activity of vegetative nervous system [28]. After stimulation the heightened slow-wave activity and parasympathetic tonus can be kept for one day (the aftereffect). In papers of L.X.Garkavy and joint authors [3], there was proved that such electrophysiological picture correlates with antistress reaction of training of the animals and human being.  Exactly after its development, these researchers join the forming of SCENAR-therapy effects. The mechanism of SCENAR-therapy impact is not studied enough. Taking into account the broad pathology spectrum, the researchers make guess-work about the non-specific character of its therapeutic action, i.e. about the active participation of reciprocal non-specific adaptive organism reactions [3, 8].

The mechanism of SCENAR-therapy impact, by data of some authors, is explained as nervous-reflex mechanism with activation of neurohumoral element through the local, segmental and generalized reactions [5, 17], and also from the position of the theory of functional systems forming (after P.K. Anohin) [8, 18]. Recently, some of the researchers have tried to examine various forms of vital activity and also the condition of disease in terms of informative principle [8, 20]. They admit that the basis of disease is formed by dyscrasia (disorder of substances, energies and information), some it becomes evident that one of the tendency of treatment is normalization of the indexes. The medical effects of many modern physiotherapy methods are pointed to activation of protecting organism mechanisms by principle of self-regulation, and some methods of traditional medicine provides the recovery of such homeostasis indexes as energy and information. So the SCENAR-therapy can be examined as the method of orthodox medicine (the section of electrotherapy) on the one side, but the principles and methodology brings it together with traditional methods [18]. Among the main medical effects of SCENAR-therapy we can marked my(o)neurostimulative, analgetic, trophic, local vasoactive, immunomodulatory and etc.[7]

It’s marked, that SCENAR-therapy, parallel with elimination of disorders, determined by the main disease, produces positive shifts from the direction of attendant pathology. Such wide spectrum of SCENAR-therapy impact is explained by the fact that for various diseases, without reference to localization of pathologic process, there can be reactions of the same type, supporting the mobilizing of pathogenesis mechanisms and increasing of organism resistance [3].Finally, the effect of SCENAR-therapy is formed under the participation of various regulative organism systems, they are: nervous, hormonal, immune, etc [6, 18]. Among the pantoclinical effects of SCENAR-therapy, it’s important to point out the activity inhibition of ??? product, producing the antimitotic and cytotoxic actions on alive cells and tissues [16, 23].After the course of SCENAR-therapy is pointed the increasing of activity of catalase and the whole peroxidase activity within 3 and 1,5 times correspondingly, and the decreasing of malonic dialdehyde (???) within 25-30%[2].

The influence of SCENAR-therapy on common adaptive possibilities of organism is appeared in tonus optimization of sympathetic and parasympathetic departments of vegetative nervous system (VNS) [3]. So, the SCENAR-therapy mobilizes the mechanisms, controlling the processes of regeneration, adaptation and regulation, both on local and common levels. These provide the appropriate answer of the organism on the influence of various external agents, demanding the corresponding reactions. In this connection, the SCENAR-therapy method can be applied for various pathologic conditions with the purpose of stimulation of the adaptation processes and the elimination of functional disorders (at their reversibility) [18].

Nowadays SCENAR-therapy is a success in treating of radicular syndrome for the patient with spinal osteochondrosis, the diseases of peripheral nervous system, neurososes, CAD, arterial hypertension and etc.

At once, there is little information of SCENAR therapy possibilities in treating of alimentary organs diseases, including duodenal ulcer. Among the patients with gastroenterological profile, the effect of SCENAR-therapy is marked during the treating of stomach ulcer and duodenal ulcer [22], and exacerbation of chronic gastritis [19, 22], acalculous cholecystitis with biliary dyskinesia [4], chronic pancreatitis [14], during combined treatment of viral  hepatitis [15]; at the syndrome of irritated bowels [14], and during  the post-surgical period after cholecystectomy [21].

N.N.Hazova and joint authors [22] give the results of therapeutic effectiveness of SCENAR-therapy method in treating of duodenal ulcer and chronic erosive gastroduodenitis (of children) in combination with the antisecretory (omeprasol),  anthelion bacillus (metronidazole) drugs, antacids and reparants (sea-buckthorn oil). 95% of patients have the scarring of ulcerative defect after 20 days of treating.

The clinical effect was appeared by time reducing of pain syndrome (in 1-2 days), the decreasing of dyspepsia (in 2-3 days), the liquidation of palpational sickliness (in 5-7 days) and the normalization of gastrointestinal tract motion activity (quick elimination of gastroduodenitial and duodenogastric refluxes.

The improvement of condition and spirits and the normalization of dream and appetite became evident with most of children after 2-3 procedures of SCENAR-therapy. There is also described the positive effect in case of duodenal ulcer recidivating complicated by bleeding.

In a number of separate clinical researches was shown, that for the patients with stomach and duodenal ulcer, SCENAR-therapy provides the considerable decreasing of subject symptomatology at the expense of spasmolytic and analgesic action and leads to quick forming of scar, the treatment time reducing and remission prolongation [4]. At the same time, the pain syndrome is stopped usually in 2-3 days, but dyspeptic one – 3-4 days afterwards.

The disappearance of ulcer defect may be observed in 21 days for 89-92% of cases. The peculiarity of healing effect of SCENAR-therapy in case of recurrent stomach ulcer is the closing of ulcer defect by the type of marginal epithelization, and some times without  rough connecting-woven scar formation [19]. G.V.Subbotina observes after history of SCENAR-monotherapy in case of stomach and duodenal ulcer recurrent. She marked the lack of any reccurents (clinical and endoscopic data) for two years after the course of treating [19].

The main recommended zones of treating impact during SCENAR-therapy for patients with duodenal ulcer are: epigastric area and segmental reflex zones [13].

The mode of impact is labial-steady with light compression under the frequency 50-70 Hz and 120-150Hz; the duration of medical séance (exposition)is about 30 minutes; the course is 10-12 procedures daily or every other day [9]. The electro puncture method is also used on appropriate biologically active points [24].

P.P.Lashedko points out the possibility of using SCENAR-therapy with the aim of decreasing of curculatory-microrculatory hypoxia degree and prevention of its development to the patients with erosive-ulcer defects of mucous of stomach and duodenum.  At the same time it’s recommended to start the treating within the next few hours after operation, the procedures must be done every day or two times a day and the impact on the projection area of solar plexus must be also done [12].

Starting from the stomach ulcer pathogenesis conception [25], in keeping with it in its development take part not only local factors of pathogenesis (acido peptic and infectious), but also the disfunctions of adaptive regulation and self-regulation mechanisms, stomach functions on various levels, starting with gastroduodenitial self-regulation system and ending with corticosubcortical relations, the using of SCENAR-therapy during the stomach ulcer recurrent is pathogenetically justified.

At the same time, the specific mechanisms of SCENAR-therapy medical impact during the stomach ulcer recurrent, particular, the character of its influence on acid-forming and motor function of stomach, contamination mucous coat of stomach Hp-infection, the activity and intensity of associated with SU chronic gastritis, vegetative and psycho emotional status of patients, the condition of lipid peroxidation and cerebral hemodynamics  are not studied well. In this connection, we developed the research of SCENAR-therapy medical impact effectiveness during the stomach ulcer recurrent, first of all from the position of its influence on common pathogenetic factors of ulcer-forming [1, 10, and 26].

Task of the Research

To study the possible mechanisms of SCENAR-therapy medical impact on the patients with stomach and duodenal ulcer and estimate its clinical effectiveness both as monotherapy and as a complex with traditional pharmacotherapeutic means (antisecretory and anthelion bacterium) during duodenal ulcer recurrent.

Materials and Methods

72 patients (56 man and 16 women) with clinical and endoscopic signs of duodenal ulcer at the age of 16-65 years (average age was 27,8±1,4years) were examined. They were divided into 3 groups. The first group (26 patients) was treated with the SCENAR-monotherapy, by the devices “SCENAR-97.1” and “SCENAR-97.4” in continuous and individually dosated regimen during 30 minutes (the course is consisted of 10 séances). The 2nd group (21 patients) got SCENAR-therapy against in common with antisecretory therapy (omeprazole 40mg/day, for 2 weeks), the 3rd group (25patients) – got SCENAR-therapy in conjunction with “threefold” 7-daily scheme of eradicative therapy (omeprazole 40mg/day, clarithromycin 1000mg/day, amoxicillin 2000mg/day).

In all groups the impact was done on the epigastric area by segmental-reflex method and transcerebrally by the common influence method [13]. The control group consisted of 25 patients with DU, who got just traditional antiulcer pharmacotherapy.

The duration of disease averages 6,87±1,13 years (from 1 to 30 years). 23 patients (31,94%) suffer this disease for the first time, and the slight and medium-weight clinical course was made with 49 patients (68,06%). The patients with complicated duodenal ulcer course were not included. As for attendant diseases, arterial hypertension were detected at 3 patients (4,2%), chronic bronchitis were detected at 2 patients (2,8%) and vegetative dystonia – at 11 patients. Initially by ???, 59 (819%) of patients suffer from single ulcers, and 13 (18,1%)- from double (“mirror”)  ulcers. At the same time the average proportions of duodenal ulcers were 0,75±0,04cm. The estimation of clinical symptoms were made before treating (the presence of pain syndrome and its’ intensity, dyspepsical effects in the form of heartburn, eructation, nausea and vomiting), ???, endogastric express-pH- metria (with pH registration in cardiac orifice, body and antral department of ulcer).  During the treating were estimated the dynamics of clinical symptoms – first from 2-weeks therapy course, and then – every week, up to the absolute scarring of ulcer defect, the endoscopic control after the condition of mucous coat of stomach and ??? were made, morphologically and with the help of quick urease test were estimated the quality of its contamination Hp, the activity and intensity of inflammatory process. The secretory and motor function of stomach were investigated in dynamics, the vegetative and psycho emotional status of patient were also investigated.

Results and Discussions 

The overwhelming majority of patients before the course of (medical) treatment complained on day and night pains in epigastric, dyspepsical effects of various quality of intensity: heartburn – 55 (76,4%), eructation and vomiting – 13 (18,1%) and 4 (5,6%) of patients. The including of SCENAR-therapy in complex of medical measures was determined by more quick in comparison with control, the liquidation of pain, dyspepsical and asthenovegetative syndromes. In control group the pain syndrome reduction occurred in 2-3 days after, the asthenovegetative effect continued for 4 days longer, the liquidation time of objective clinical symptoms of disease recurrent (local palpatory pain, Mendel’s symptom and the symptom of muscular defense).The quickest liquidation of dyspepsical effect occurred in group of patient who have got SCENAR-therapy with omeprazolon. The asthenovegetative complaints reduced and eliminated in this group (in 3-6 days). SCENAR-monotherapy influenced positively on intensity of pain syndrome.

The essential decreasing of epigastric pain was evident in 2 days (after 1-2 procedures). The analgesic effect of SCENAR-therapy is explained by its possibility for activation of fine peptide nerve fiber and mediates changing in brain tissue of biologically-active materials, which have antinociceptive qualities (glutamic and aspartic acids, serotonin etc.) [6,28], and also by elimination of gastric dismotor, which underlines the pain syndrome during duodenal ulcer. The important criterion of treating was endoscopic research (???-control) of gastro duodenal zone condition (table 1). The scheme of treating with using of SCENAR-monotherapy and its combination with “triple” eradicable therapy allowed to have the quickest speed of ulcer defect scarring.

So, in two weeks of treating the ulcer wasn’t defined in 1st group at 65,38% of patients and at 64% in 3rd group, and after 3 weeks, there are the whole healing with all the patients. At the same time in control group the ulcer defect eliminated at 48% and 76% of patients in 2 and 3 weeks.

Table 1

The time of duodenal ulcers scarring

The group of patients In 2 weeks

(abs, %)

In 3 weeks

(?bs, %)

Time(days)
I group(n=26) 17 (65,38%) 26 (100%) 16,2± 0,68

p<0,05

II group (n=21) 12 (57,14%) 19 (90,48%) 17,12± 1,05

p>0,05

III group (n=25) 16 (64%) 25 (100%) 16,52± 0,69

p?0,05

The control n=25) 12 (48%) 19 (76 %) 19,32±1,16

As a whole, the average time of ulcer scarring in groups with using of SCENAR-therapy is shorter on 3-4days in comparison with control (on average 16,71±0,47 days), here some of the patients as opposed to control group had epithelization of ulcer defect without forming of rough connecting-woven scar. Against a background of treating the diffuse gastroduodenitis of 76,4% of patients transformed in focal one, and mucous tunic was absolutely normal for 4 patients (5,6%). Under the results of quick urease test, breathing test and histological research of biopsy material (methylene blue coloring), most of patients (83,3%) have contamination mucous coat of stomach Hp-infection. The course of SCENAR-therapy didn’t lead to Hp eradication in 1st and 2nd group, but the quality of mucous coat of stomach Hp colonization after the SCENAR-therapy reduced incidentally (p>0,05). At the same time as for the 3rd group, the Hp-infection eradication began by the results both of urease, breathing test and morphological data. As for the 3rd group after the therapy there were occurred the semination in pyloric department mucous coat of stomach Hp-infection (4 patients – 16%)-by the results of quick urease test, and by morphological test – with 3 patients (12%). So, the positive eradication was seen in 88% of cases in 3rd group.

Before the treating most of the patients (84,7%) had the evident hyperacidity of body and antral department of stomach, the moderate hyperacidity (15,3 % of patients) and norm acidity in 2,8%. After the course of SCENAR-monotherapy the increasing of pH in body and antral department of stomach are registered, the increasing of pH level in all departments of stomach (p,0,001) is marked  when SCENAR-therapy was  in conjunction with omeprasol and “triple” scheme of Hp eradication. The immature zone (the place of transition of subacid pH (6,0-4,0)value up to sharply acid (pH<3,0) didn’t undergo any essential changing. There became reliable decreasing of zone of maximal acidity in all investigated groups. The combined therapy in the conjunction with antisecretory and anthelicobacterian

Substances provided the defined abscopal effect on the acid-forming processes in stomach, but the pH-metria indicators in basic groups didn’t differ from one in control group. The including of SCENAR-therapy in combined treatment of duodenal ulcer recurrent had “modulatory” impact on the condition of stomach motor function. When the stomach motor activity is initially decreased, the growth of frequency indicators of stomach motor oscillations, their average amplitude and total intensity of stomach biopotentials came to 31,4%, 75,4 % and 139,1 % conformably, and finally they’ve got normal condition. During the initial hyper kinesis, there are marked the decreasing of electrogastrography indicators half as less again (p<0,001). There are discovered the possibility of SCENAR-influence to remove the manifestations of dyskinesia, which has been proved by the increasing of symmetric (from 34% to 91%) and single modal (from 49% to 96%) variational curve amplitude (VCA)  in all the investigated groups.

During the studying the VNS condition the parasympathetic tonus of nervous system prevailed in most cases (76,3% of patients), and sympathetic one- in others (13,9%-of patients). Including the hyper vagotonia, which was evident for 43,1% of patients and hyper sympathicatonia (5,6% of patients) [1]. Vegetative reactivity (VR) for most of patients (39.3%) was unnatural; this proved the predomination parasympathetic tonus of nervous system. The redundant VR was marked at 10,7% of patients and was connected with initial sympathicatonia. There was detected the overstrain of both department of nervous system during the security of action (SA), and 68,4% of patients showed the  disfunction of balance and correlation between them. The including of SCENAR-therapy in treating of duodenal ulcer recurrent led to the normalization of not only initially unnatural but also initially redundant vegetative reactions (p<0,05), and also provided the decreasing of  heightened indicators either of clinostatic (p<0,02) or orthostatic (p<0,05) probes. Here at the background of pharmacotherapy (control) the vegetative status hasn’t change much.

Conclusions

The including of SCENAR-therapy in combined treatment during the duodenal ulcer recurrent, positively influences on clinical course and functional condition of gastro duodenal zone, stimulates reparative processes and decreases the inflammation activity of mucous coat of stomach. In mechanisms of medical influence of SCENAR-therapy, there such predominating factors as the activation of indicators of “defiance” and the impact on common mechanisms of adaptive regulation of gastro duodenal zone self-regulation [5].

Al the researches let us talk about SCENAR-therapy as the effective method of duodenal ulcer recurrent treatment, either like monotherapy or as a component in combined medicine treatment.

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